Science News May 2021: Mushroom Extract Powders, NMN and more!

As we are welcoming more sunshine and warmth, it's good to reflect on the latest scientific headlines on nutrition. Here's a selection of interesting headlines and science stuff related to our mushroom extracts!

Anti-ageing compound improves muscle glucose metabolism in people

In the clinical trials regarding nicotinamide mononucleotide (also known as NMN), findings from the research show us that that the compound has clinically relevant effects in humans (1).
NMN is one of the agents that is key to producing an important compound in all cells, which is called nicotinamide adenine dinucleotide (abbreviated as NAD), and NAD is vital in keeping mammals healthy.
NAD levels tend to decline with ageing in mammals, including humans. The compound contributes to a variety of ageing-associated problems, such as insulin resistance.

Sugar-sweetened drinks linked to increased risk of colorectal cancer in women under 50, study finds

The rate of diagnoses, marked by the keyword 'colorectal cancer' have increased for people below the age of 50 in recent years. Researchers have conducted a study which has succeeded in finding a link between the consumption of sugar-sweetened beverages and the pathology. Findings say that the use of sugary drinks during adolescence (between ages 13 to 18) and then adulthood (above 18) may increase the risk for the disease (2).

Mushroom-supplemented soybean extract shows therapeutic promise for advanced prostate cancer

The research focused on GCP, a proprietary extract cultured from soybeans and shiitake mushrooms and marketed by Amino-Up of Sapporo, Japan. Researchers found that the combination of the compounds genistein and daidzein, both present in GCP, helps block a key mechanism used by prostate cancer cells to survive in the face of testosterone deprivation.
The research team had earlier shown that when a patient's androgen level goes down, cancerous prostate cells kick out a protein known as filamin A, which is otherwise attached to the androgen receptor in the cell's nucleus. The androgen receptor regulates the growth of prostate cancer cells. Once filamin A leaves the cancerous cell's nucleus, that cell no longer requires androgens to survive. Thus, loss of filamin A allows these cells to survive androgen deprivation, and the cancer essentially becomes incurable.
The paper, titled "Enhancing the effectiveness of androgen deprivation in prostate cancer by inducing Filamin A nuclear localization," shows for the first time that GCP keeps filamin A in the nucleus. As long as this protein remains attached to the androgen receptor, the cancerous cells need androgens to survive and grow. They die off when starved of androgens, thus prolonging the effects of androgen deprivation, which ultimately prolongs the patient's life.
The team's hypothesis is that metastatic prostate cancer patients with the weakest response to androgen-deprivation therapy could be given GCP concurrently with androgen deprivation therapy to retain Filamin A in the nucleus, thereby allowing cancer cells to die off (3).

Stay tuned for more!

Our team at Forest Mana are always up to date with the latest scientific headlines on nutrition and mushroom supplements. We love sharing the information with our lovely health-nut community, after translating it into human language.
If you love being informed then please join our mailing list and we'll keep in touch with the good news... as well as special offers for our premium mushroom extract powders!

Science News for June 2021 coming soon.

  1. Mihoko Yoshino, Jun Yoshino, Brandon D. Kayser, Gary Patti, Michael P. Franczyk, Kathryn F. Mills, Miriam Sindelar, Terri Pietka, Bruce W. Patterson, Shin-Ichiro Imai, Samuel Klein. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science, 2021; eabe9985 DOI: 10.1126/science.abe9985
  2. Jinhee Hur, Ebunoluwa Otegbeye, Hee-Kyung Joh, Katharina Nimptsch, Kimmie Ng, Shuji Ogino, Jeffrey A Meyerhardt, Andrew T Chan, Walter C Willett, Kana Wu, Edward Giovannucci, Yin Cao. Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women. Gut, 2021; gutjnl-2020-323450 DOI: 10.1136/gutjnl-2020-323450
  3. University of California - Davis Health System. "Mushroom-supplemented soybean extract shows therapeutic promise for advanced prostate cancer." ScienceDaily. ScienceDaily, 20 February 2013.

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